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Overview
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The purpose of this project is to improve adherence to hydroxyurea therapy. Multiple approaches for improving adherence with pharmaceutical regimens have been studied and demonstrate a need to address barriers that both providers and patients face. This project aims to test two innovative interventions utilizing mobile health (mHealth), to address both patients’ and providers’ needs: 1) an mHealth application for patients (InCharge Health app) that includes multi-component features to address the memory, motivation, and knowledge barriers to hydroxyurea use, and 2) an mHealth toolbox application for providers (HU Toolbox app) that addresses the clinical knowledge barriers in prescribing and monitoring hydroxyurea use.
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Focus Areas
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1. Improve Patient Adherence to Hydroxyurea: Addressing Memory, Motivation, and Knowledge Barriers to Hydroxyurea Use.
2. Improve Provider Hydroxyurea Awareness, Prescribing and Monitoring Behaviors.
3. Identify and Evaluate the Barriers and Facilitators to the use of mHealth Interventions.
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Outcomes
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1. Measure of the association between InCharge Health app to patient hydroxyurea adherence [ Time Frame: baseline (prior to the intervention), week 12, week 24 ]
2. Implementation of InCharge Health app. [ Time Frame: baseline, 24 weeks, 36 weeks]
3. Change in mean corpuscular volume (MCV) [ Time Frame: baseline, 24 weeks]
4. Change in fetal hemoglobin [ Time Frame: baseline, 24 weeks ]
5. Change in mean hemoglobin concentration [ Time Frame: baseline, 24 weeks ]
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