1. The duration of signs and symptoms of ACS or duration of hospitalization, whichever is less. The duration of signs and symptoms of ACS is defined as the interval between study entry and the time at which tachypnea, hypoxemia, increased work of breathing, and thoracic pain have resolved and supplemental oxygen and ventilatory support are no longer utilized.
2. Clinical endpoints include: rating of pain, duration of hospitalization, supplemental oxygen, hypoxemia, and fever, number of transfusions, quantification of opioid use, rebound hospitalizations, pulmonary radiographic findings, and pulmonary function testing results. Laboratory endpoints include: VCAM1, ICAM1, P-selectin, L-selectin, vWF multimers, endothelial and monocyte microparticles, WBTF, NO, and sPLA2.