Overview
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In Phase I, approximately 156 subjects will participate in a cross-sectional studyconsisting of screening questionnaires, a neuropsychological testing battery, and MRI testing. InPhase II, a subset of approximately 30 participants will be asked to participate in a transfusionintervention. Half will be randomized to undergo a chronic transfusion regimen for six months, and theother half will be treated with standard care alone, guided by their disease symptoms.
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